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In contrast with mouse thymocytes, mouse ES cells include greater levels of complete genomic H3K4me3 and have greater H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 46 In agreement with this, international decreases in H3K4me3 ranges happen during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at particular units of genes throughout ES cell differentiation.
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