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Compared with mouse thymocytes, mouse ES cells comprise higher ranges of complete genomic H3K4me3 and have higher H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In agreement with this, world decreases in H3K4me3 levels happen throughout retinoic acid (RA)-induced differentiation of mouse ES cells forty seven As well as, there are dynamic modifications in H3K4me3 profiles at particular units of genes during ES cell differentiation.
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